The Binding of Isaac: Rebirth The Cleaver Setup Guide

Publish date: 2024-07-16

Quick Guide to The Cleaver Setup

Break the game. Exhaust the secret room pool. You’ll want to look for Death Certificate, D Infinity, Red Key, Forget Me Now, Esau Jr and Strawman. If you’ve already used Death Certificate, you’ll have to get it back later with Bag of Crafting. Glitched Crown is NOT recommended unless you absolutely need it to continue the break. Echo Chamber is also not recommended, as it may cause issues later on.

Exhaust the shop pool. The only items you absolutely need are Diplopia, Schoolbag, Habit and The Battery, although you’ll most likely want Sharp Plug, Starter Deck, 9 Volt, Deep Pockets and Humbleing Bundle as well. Crooked Penny and Glowing Hourglass are optional, but can be used together as an alternative to Diplopia duping, so save them somewhere on the floor if you want.

Move a trinket to an empty room and use D1 repeatedly until you have the Butter trinket. This will allow you to easily move actives around.

Next, you’ll need two ? cards. Using D20 repeatedly on a large amount of pickups is the fastest way to find one. Look for a Jera in the process, as you can simply dupe the first ? card with Jera instead of finding a second one. Once you have two ? cards, you’ll be able to dupe items and pickups with Diplopia infinitely.

Move Death Certificate to an empty room and dupe it a few times. The items you’ll want to take from the Death Certificate floor (assuming you don’t have any of them yet) are Void, Meat Cleaver and Yum Heart. If you’re missing any other important items, such as Dull Razor, now is a good time to get them. You may also want an infinite-use active if you don’t have one already.

Move Dull Razor to an empty room and dupe it until you have eight Dull Razors. You only need six of them, so move two of the copies somewhere else. After that, move Red Key, Meat Cleaver and Yum Heart to the room. Once you’re ready, void everything. You now have an infinite-use Void that can open red rooms, cleaver enemies and heal your strawmen. (If you plan on using Clear Rune with Soul of Cain, void that instead of Red Key.)

Return to the room with Strawman. If there are other items in the room, either pick them up (if they’re passives) or move them out of the room (if they’re actives). If there’s a passive that you can’t pick up, like TMTRAINER, keep using Soul of Isaac until the pedestal has cycled to either a harmless passive that you can pick up or an active that you can move out of the room. The fastest way to get a Soul of Isaac is by using D1 repeatedly on a rune, and you can dupe it afterwards just in case you need multiple copies. After you’ve isolated the Strawman pedestal, dupe it until you have 64 strawmen in the room.

This step is optional, but recommended. While clearing rooms with this setup, it’s possible to accidentally void unwanted actives, putting your run at risk. You can help avoid this by breakfasting as many item pools as possible. This can be quickly done by taking Glitched Crown and Chaos from Death Certificate and spamming D6 in a room with multiple pedestals until everything is breakfast. Note that rerolls with Chaos tend to ignore certain pools if there’s a small amount of items in them, so you may still see items even after doing this.

If you’re not already holding Void, pick it up. At this point, you’ll have to decide what you want to carry in your 2nd active slot.

Once you’re ready, return to the room with the strawmen and take up to 63 of them (62 if you’re J&E). You can take less than 63 if you’re worried about crashing. Make sure to let the strawmen pick each other up. This keeps them tightly clumped together. If you don’t do this, the strawmen will push each other around a lot, which could potentially activate 1-pip and 6-pip dice rooms as soon as you enter them.

You can start 13x13ing now. Enter a room, spam Void until everything is dead, and repeat. Be careful not to use Void in rooms with actives, be careful around dice rooms, and be careful not to enter error rooms. Always double check to make sure you have everything you need before leaving a floor or using FMN.

Once you’re satisfied with your score, kill the final boss of the run, use Esau Jr and touch the trophy.

Additional Notes

If you need a Strawman pedestal and happen to have him in your inventory, you can use a The Fool? card with Tarot Cloth to remove your most recent passive items, dropping him on the ground.

D12 can reroll rocks into trapdoors, allowing you to go past the intended goal if you spawn a trapdoor on the final floor. You can also loop Chest and Dark Room using this method. If this is something you’re interested in doing, bring D Infinity, Blank Card and a The Tower? card with you inside Moving Box. This will allow you to spawn and reroll rocks infinitely.

I sincerely hope this was helpful. Good luck to you!

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